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Head of Engineering

Early-stage biotech innovator San Francisco, CA Direct Hire Biotech & Life Sciences $250,000 - $350,000

Job Summary

Join an early-stage biotech team as a Founding Engineering Lead and player-coach with 5-10 years of experience scaling startups through Series A and B. Own the technical direction across the full stack, from agentic AI systems to web applications, while building a high-performing engineering team. This role offers hands-on coding alongside strategic leadership to drive product quality and rapid iteration grounded in customer needs.

Essential Functions

  • Build, lead, and grow the engineering team through hiring, setting technical standards, and developing engineers.
  • Stay hands-on by writing production code, reviewing pull requests, and debugging with the team.
  • Own technical direction across the full stack, including agentic systems, RAG pipelines, and data infrastructure.
  • Establish engineering practices and culture enabling a small team to ship quickly while maintaining customer trust.
  • Partner with founders on roadmap and strategy, aligning technical decisions with customer requirements.
  • Scale engineering from 1-10 or 10-100 engineers in fast-growth environments.

Required Qualifications

  • 10+ years of full-stack or backend-leaning engineering experience at VC-backed tech startups.
  • Proven track record scaling teams from 1-10 or 10-100 at top-tier tech companies.
  • Experience building monitoring, alerting, and quality evaluation systems at scale.
  • AI efficiency expertise; ability to communicate technical concepts to non-technical stakeholders.
  • Technical undergraduate degree from a top 20 school.

Preferred Qualifications

  • Mix of big tech and startup environments.
  • Health tech or pharma tech experience.
  • Proficiency in TypeScript and Next.js.
  • VC-backed experience with strong engineering culture.
  • Full stack experience, backend leaning.

Technical Skills

  • Full-stack development
  • Backend engineering
  • Agentic AI systems
  • RAG pipelines
  • Data infrastructure
  • TypeScript
  • Next.js
  • Monitoring and alerting systems
  • Quality evaluation frameworks
  • Production code deployment

Education & Certifications

Technical undergraduate degree from a top 20 school required.

Compensation & Benefits

Competitive base salary range of $250,000 - $350,000 annually, depending on experience, plus equity in an early-stage biotech venture. Hybrid work model in San Francisco, CA.

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